Hideo KIGOSHI

Bioorganic Chemistry 　

Professor　D.Sc 1989,Nagoya University

　TEL +81-29-853-4313　FAX +81-29-853-4313

Isolation, structures, and synthesis of bioactive natural products.
Molecular mechanisms of bioactivities of natural products.

◇ Cytotoxicity and Actin-Depolymerizing Activity of Aplyronine A, a Potent Antitumor Macrolide of Marine Origin, and Its Analogs, H. Kigoshi, K. Suenaga, M. Takagi, A. Akao, K. Kanematsu, N. Kamei, Y. Okugawa, and K. Yamada, Tetrahedron, 58, 1075-1102 (2002).
◇ Auriculol, a Cytotoxic Oxygenated Squalene from the Japanese Sea Hare Dolabella auricularia: Isolation, Stereostructure, and Synthesis, H. Kigoshi, T. Itoh, T. Ogawa, K. Ochi, M. Okada, K. Suenaga, and K. Yamada, Tetrahedron Lett., 42, 7461-7464 (2001).
◇ Synthetic Studies of Ingenol: Synthesis of in,out-Tricyclo[7.4.1.01,5]tetradecan-14-one, H. Kigoshi, Y. Suzuki, K. Aoki, and D. Uemura, Tetrahedron Lett., 41, 3927-3930 (2000).