Hiroshi Nagase

Medicinal Chemistry

Specially Appointed ProfessorF D. Sc. 1978, Nagoya University

@@TEL +81-29-853-6437

Design and synthesis of orexin receptor agonists and antagonists.
Design and synthesis of opioid receptor selective agonists.
Release of drugs to the market about analgesics, sleep control drugs, antidepressant, and anti-anxiety drugs.

H. Nagase, N. Yamamoto, M. Yata, S. Ohrui, T. Okada, T. Saitoh, N. Kutsumura, Y. Nagumo, Y. Irukayama-Tomobe, Y. Ishikawa, Y. Ogawa, S. Hirayama, D. Kuroda, Y. Watanabe, H. Gouda, M. Yanagisawa, "Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies" J. Med. Chem. 2017, 60, 1018-1040.
T. Nagahara, T. Saitoh, N. Kutsumura, Y. Irukayama-Tomobe, Y. Ogawa, D. Kuroda, H. Gouda, H. Kumagai, H. Fujii, M. Yanagisawa, H. Nagase, "Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists" J. Med. Chem. 2015, 58, 7931-7937.
K. Kawai, J. Hayakawa, T. Miyamoto, Y. Imamura, S. Yamane, H. Wakita, H. Fujii, K. Kawamura, H. Matsuura, N. Izumimoto, R. Kobayashi, T. Endo, H. Nagase, "Design, synthesis, and structure-activity relationship of novel opioid -agonists" Bioorg. Med. Chem. 2008, 16, 9188-9201.