長瀬　博

創薬化学 ： 特命教授 ： 理学博士, 1978, 名古屋大学

　TEL 029-853-6437

オレキシン受容体選択的作動薬・拮抗薬の設計と合成、
オピオイド受容体選択的作動薬の設計と合成、
鎮痛薬・睡眠制御薬・抗鬱・抗不安薬の創出

◇ H. Nagase, N. Yamamoto, M. Yata, S. Ohrui, T. Okada, T. Saitoh, N. Kutsumura, Y. Nagumo, Y. Irukayama-Tomobe, Y. Ishikawa, Y. Ogawa, S. Hirayama, D. Kuroda, Y. Watanabe, H. Gouda, M. Yanagisawa, "Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies" J. Med. Chem. 2017, 60, 1018-1040.
◇ T. Nagahara, T. Saitoh, N. Kutsumura, Y. Irukayama-Tomobe, Y. Ogawa, D. Kuroda, H. Gouda, H. Kumagai, H. Fujii, M. Yanagisawa, H. Nagase, "Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists" J. Med. Chem. 2015, 58, 7931-7937.
◇ K. Kawai, J. Hayakawa, T. Miyamoto, Y. Imamura, S. Yamane, H. Wakita, H. Fujii, K. Kawamura, H. Matsuura, N. Izumimoto, R. Kobayashi, T. Endo, H. Nagase, "Design, synthesis, and structure-activity relationship of novel opioid κ-agonists" Bioorg. Med. Chem. 2008, 16, 9188-9201.