論文リスト (Publication List)

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早川一郎 (Ichiro Hayakawa)

原著論文

  1. Hirokazu Arimoto, Ichiro Hayakawa, Makoto Kuramoto, and Daisuke Uemura:
    Absolute Stereochemistry of Halichlorine; A Potent Inhibitor of VCAM-1 Induction.
    Tetrahedron Lett., 39 (8), 861−862 (1998).
  2. Hirokazu Arimoto, Kazuya Nishimura, Tomoya Kinumi, Ichiro Hayakawa, and Daisuke Uemura:
    Multi-valent Polymer of Vancomycin: Enhanced Antibacterial Activity against VRE.
    Chem. Commun., (15), 1361−1362 (1999).
  3. Yoshiaki Kamano, Ayano Kotake, Hirofumi Hashima, Ichiro Hayakawa, Hatsue Hiraide, Hui-ping Zhang, Haruhisa Kizu, Kanki Komiyama, Masahiko Hayashi, and George R. Pettit:
    Three New Alkaloids, Convolutamines F and G, And Convolutamydine E, from the Floridian Marine Bryozoan Amathia convoluta.
    Collect. Czech. Chem. Commun., 64 (7), 1147−1153 (1999).
  4. Ichiro Hayakawa, Hirokazu Arimoto, and Daisuke Uemura:
    Synthesis of (+/−)-Pinnaic Acid.
    Heterocycles, 59 (2), 441−444 (2003).
  5. Ichiro Hayakawa, Hirokazu Arimoto, and Daisuke Uemura:
    Synthesis of the tricyclic core of halichlorine.
    Chem. Commun., (10), 1222−1224 (2004).
  6. Ichiro Hayakawa, Toshiaki Teruya, and Hideo Kigoshi:
    Revised Structure of Zamamistatin,
    Tetrahedron Lett., 47 (2), 155−158 (2006).
  7. Kiyotake Suenaga, Hiroshi Hoshino, Takanori Yoshii, Kazunori Mori, Hiroki Sone, Yuhki Bessho, Akira Sakakura, Ichiro Hayakawa, Kiyoyuki Yamada, and Hideo Kigoshi:
    Enatioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin.
    Tetrahedron, 62 (33), 7687−7698 (2006).
  8. Ichiro Hayakawa, Yuki Asuma, Takayuki Ohyoshi, Kenta Aoki, and Hideo Kigoshi:
    Synthetic study on 13-oxyingenol: Construction of the full carbon frame work.
    Tetrahedron Lett., 48 (35), 6221−6224 (2007).
  9. Ichiro Hayakawa, Akiyuki Ikedo, and Hideo Kigoshi:
    Synthesis of Glaziovianin A: A Potent Antitumor Isoflavone.
    Chem. Lett., 36 (11), 1382−1383 (2007).
  10. Tomoyuki Kimura, Satomi Kuribayashi, Tetsuya Sengoku, Keita Matsui, Shoko Ueda, Ichiro Hayakawa, Kiyotake Suenaga, and Hideo Kigoshi:
    Synthetic Studies on Mycalolide B: Synthesis of the C7−C35 Fragment.
    Chem. Lett., 36 (12), 1490−1491 (2007).
  11. Ichiro Hayakawa, Mitsuru Ueda, Masashi Yamaura, Yoichi Ikeda, Yuta Suzuki, Kensaku Yoshizato, and Hideo Kigoshi:
    Second-Generation Total Synthesis of Haterumalide NA Using B-Alkyl Suzuki−Miyaura Coupling.
    Org. Lett., 10 (9), 1859−1862 (2008).
  12. Ichiro Hayakawa, Hidekazu Watanabe, and Hideo Kigoshi:
    Synthesis of ustalic acid, an inhibiter of Na+,K+-ATPase.
    Tetrahedron, 64 (25), 5873−5877 (2008).
  13. Masaki Kita, Yuta Tsunematsu, Ichiro Hayakawa, and Hideo Kigoshi:
    Structure of zamamistatin - a correction.
    Tetrahedron Lett., 49 (37), 5383−5384 (2008).
  14. Tetsuya Sengoku, Takuma Takemura, Emi Fukasawa, Ichiro Hayakawa, and Hideo Kigoshi:
    Aldol-type reaction of a 4-pyrone: a straightforward approach to 4-pyrone-containing natural products.
    Tetrahedron Lett., 50 (3), 325−328 (2009).
  15. Takashi Yoshizumi, Akio Ohno, Tomohiro Tsujita, Hirobumi Takahashi, Osamu Okamoto, Ichiro Hayakawa, and Hideo Kigoshi:
    Practical Syntheses of Optically Pure Key Intermediates of Opioid Receptor-like 1 (ORL1) Antagonists.
    Synthesis, (7), 1153−1162 (2009).
  16. Mitsuru Ueda, Masashi Yamaura, Yoichi Ikeda, Yuta Suzuki, Kensaku Yoshizato, Ichiro Hayakawa, and Hideo Kigoshi:
    Total Synthesis and Cytotoxicity of Haterumalides NA and B and their Artificial Analogues.
    J. Org. Chem., 74 (9), 3370−3377 (2009).
    *Highlighted in Synfacts (1), 9 (2010).
  17. Ichiro Hayakawa, Takuma Takemura, Emi Fukasawa, Yuta Ebihara, Natsuki Sato, Takayasu Nakamura, Kiyotake Suenaga, and Hideo Kigoshi:
    Total Synthesis of Auripyrones A and B and Determination of the Absolute Configuration of Auripyrone B.
    Angew. Chem. Int. Ed., 49 (13), 2401−2405 (2010); Angew. Chem., 122 (13), 2451−2455 (2010).
    *Highlighted in Synfacts (7), 738 (2010).
  18. Akiyuki Ikedo, Ichiro Hayakawa, Takeo Usui, Sayaka Kazami, Hiroyuki Osada, and Hideo Kigoshi:
    Structure−activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
    Bioorg. Med. Chem. Lett., 20 (18), 5402−5404 (2010).
  19. Ichiro Hayakawa, Yamato Miyazawa, Takayuki Ohyoshi, Yuki Asuma, Kenta Aoki, and Hideo Kigoshi:
    Synthetic studies toward optically active 13-oxyingenol via asymmetric cyclopropanation.
    Synthesis, (5), 769−777 (2011).
  20. Kenichi Kobayashi, Yusuke Fujii, Ichiro Hayakawa, and Hideo Kigoshi:
    Toward the Second Generation Synthesis of Aplyronine A: Stereocontrolled Assembly of the C1-C19 Segment by Using an Asymmetric Nozaki-Hiyama-Kishi Coupling.
    Org. Lett., 13 (5), 900−903 (2011).
  21. Takayuki Ohyoshi, Yamato Miyazawa, Kenta Aoki, Satomi Ohmura, Yuki Asuma, Ichiro Hayakawa, and Hideo Kigoshi:
    Synthetic Studies Toward 13-Oxyingenol: Construction of the Fully Substituted Tetracyclic Compound.
    Org. Lett., 13 (9), 2160−2163 (2011).
  22. Yohsuke Satoh, Dai Kawamura, Masashi Yamaura, Yoichi Ikeda, Yumi Ochiai, Ichiro Hayakawa, and Hideo Kigoshi:
    Synthetic studies towards biselides. Part 1: Synthesis of the core carbon framework of biselides A, B, and E using Stille coupling.
    Tetrahedron Lett., 53 (11), 1390−1392 (2012).
  23. Yohsuke Satoh, Takuya Yamada, Yuto Onozaki, Dai Kawamura, Ichiro Hayakawa, and Hideo Kigoshi:
    Synthetic studies toward biselides. Part 2: Synthesis of the macrolactone part of biselides A and B using allylic oxidation.
    Tetrahedron Lett., 53 (11), 1393−1396 (2012).
  24. Kenichi Kobayashi, Yusuke Fujii, Yuichiro Hirayama, Shinichi Kobayashi, Ichiro Hayakawa, and Hideo Kigoshi:
    Design, Synthesis, and Biological Evaluations of Aplyronine A-Mycalolide B Hybrid Compound.
    Org. Lett., 14 (5), 1290−1293 (2012).
  25. Takayuki Ohyoshi, Shota Funakubo, Yamato Miyazawa, Keisuke Niida, Ichiro Hayakawa, and Hideo Kigoshi:
    Total Synthesis of (-)-13-Oxyingenol and its Natural Derivative.
    Angew. Chem. Int. Ed., 51 (20), 4972−4975 (2012); Angew. Chem., 124 (20), 5056−5059 (2012).
    *Highlighted in Synfacts (8), 816 (2012).
  26. Takuma Takemura, Ichiro Hayakawa, Emi Fukasawa, Tetsuya Sengoku, and Hideo Kigoshi:
    Toward the synthesis of γ-pyrone-containing natural products: Diastereoselective aldol-type reaction of a γ-pyrone.
    Tetrahedron, 68 (32), 6477−6484 (2012).
  27. Ichiro Hayakawa, Takuma Takemura, Emi Fukasawa, Yuta Ebihara, Natsuki Sato, Takayasu Nakamura, Kiyotake Suenaga, and Hideo Kigoshi:
    Total synthesis and biological evaluation of auripyrones A and B.
    Bull. Chem. Soc. Jpn., 85 (10), 1077−1092 (2012).
    *BCSJ Award Article (2012).
  28. Ichiro Hayakawa, Akiyuki Ikedo, Takumi Chinen, Takeo Usui, and Hideo Kigoshi:
    Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.
    Bioorg. Med. Chem., 20 (19), 5745−5756 (2012).
  29. Takumi Chinen, Sayaka Kazami, Yoko Nagumo, Ichiro Hayakawa, Akiyuki Ikedo, Masatoshi Takagi, Akihito Yokosuka, Naoko Imamoto, Yoshihiro Mimaki, Hideo Kigoshi, Hiroyuki Osada, and Takeo Usui:
    Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.
    ACS Chem. Biol. , 8, in press (2013). (DOI: 10.1021/cb300641h)

総説・解説記事

  1. Hideo Kigoshi and Ichiro Hayakawa:
    Marine cytotoxic macrolides haterumalides and biselides, and related natural products.
    Chem. Rec., 7 (4), 254−264 (2007).
  2. 早川一郎:
    ハリコンドリン類の実用的合成研究（Review de Debut）.
    有機合成化学協会誌, 65 (12), 1225−1226 (2007).
  3. 早川一郎:
    構造決定から22年．遂に陥落！アザジラクチンの全合成（トピックス欄）.
    ファルマシア, 44 (3), 251−253 (2008).
  4. Hideo Kigoshi and Ichiro Hayakawa
    (−)-Haterumalide NA
    天然物の全合成　2000−2008（日本）有機合成化学協会編, 化学同人, pp. 89−90 (2009).
  5. 早川一郎:
    ソレル有機化学 (Thomas N. Sorrell著 Organic Chemistry, 石橋正己, 木越英夫, 佐々木誠, 村田道雄　監訳), 第15, 16章翻訳
    東京化学同人 (2009).
  6. 早川一郎:
    有用な生物活性を示す海洋天然物の全合成と構造活性相関（飛翔する若手研究者欄）
    化学と工業, 63 (8), 654 (2010).
  7. 早川一郎, 木越英夫:
    腫瘍細胞増殖阻害マクロライド　ハテルマライドNA, Bの全合成と構造活性相関（総合論文）
    有機合成化学協会誌, 68 (8), 814−823 (2010).
  8. 早川一郎, 木越英夫:
    トリトンB（十字路欄）
    有機合成化学協会誌, 68 (8), 870 (2010).
  9. 天然物合成で活躍した反応　実験のコツとポイント　有機合成化学協会編, 化学同人, pp. 2−3（安藤オレフィン化：早川一郎, 木越英夫）, pp. 24−25（Grieco−西沢反応：早川一郎, 木越英夫）, pp. 92−93（野崎−檜山−岸反応：早川一郎, 難波康祐）の執筆を担当 (2011).
  10. 早川一郎, 木越英夫:
    ますます進化する天然物合成−実用的天然物合成の時代が見えてきた（最新のトピックス欄）
    化学, 67 (6), 70−71 (2012).

受賞

  1. 2007年9月　第49回天然有機化合物討論会奨励賞
    腫瘍細胞増殖阻害マクロライド・ハテルマライドNAメチルエステルの合成とビセライド類の合成研究
  2. 2008年10月　日本化学会　第2回関東支部大会優秀講演賞
    オレフィンメタセシス反応を鍵反応とした13-オキシインゲノールの合成研究
  3. 2010年3月　日本化学会　第24回若い世代の特別講演 (2009年度) 講演者
    腫瘍細胞増殖阻害マクロライド　ハテルマライドNA, Bの全合成と構造活性相関
  4. 2010年12月　第23回有機合成化学協会研究企画賞（明治製菓）
    海洋天然物の全合成中間体を用いたメドケム指向型構造活性相関研究による医薬品リード化合物の探索
  5. 2012年10月　BCSJ Award Article (2012) 選出
    Total synthesis and biological evaluation of auripyrones A and B
  6. 2013年2月　有機合成化学協会　第31回有機合成化学奨励賞
    生物活性天然物の全合成を起点とした生体機能分子創製への展開

(April, 2013)

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