Laboratory of Supramolecular Chemistry, University of Tsukuba

Nakamura Group, Research Outline

Natural receptor proteins can bind substrates selectively at the pocket surrounded by multiple amino acid residues. Relatively weak intermolecular interactions, such as hydrogen bonds, are synergistically exerted during the recognition events. Meanwhile, it was difficult for synthetic receptors to achieve precise molecular binding by arranging various interaction moieties in an unsymmetrical manner.
 Our group develops novel macrocyclic receptors with precise recognition properties based on two concepts, that is, (A) assembly of metal coordination sites, and (B) desymmetrization of the molecular components

 Research Concept

Our Macrocycles
  1. Hexapap: Receptors that capture molecules via multipoint coordination
    (a) Nature Commun., 8, 129 (2017). (Paper)
    (b) Chem. Commun., 55, 2421-2424 (2019). (Paper) (Inside Front Cover)
    (c) Eur. J. Inorg. Chem., 308-313 (2021). (Paper) (Cover Feature)
  2. Bpytrisalen: Spatial arrangement of different coordination sites
    (a) Inorg. Chem., 58, 7863-7872 (2019). (Paper) (Supplementary Cover)
  3. Saloph-belt: Belt-shaped macrocycles generated from a bis-armed bifunctional monomer
    (a) J. Am. Chem. Soc., 141, 6462-6467 (2019). (Paper)
  4. Amide-cyclodextrin: Multipoint hydrogen bond utilizing desymmetrized structure
    (a) Chem. Commun., 55, 3872-3875 (2019). (Paper) (Inside Front Cover)
    (b) Chem. Lett., 49, 493-496 (2020). (Paper)
    (c) Angew. Chem. Int. Ed., 60, 3080-3086 (2021). (Paper)
Recent Reviews and Books
  • “Supramolecular complexes that capture molecules by multi-point coordination bonds ”
    Bull. Jpn. Soc. Coord. Chem., 70, 39-42 (2017).
  • “Development of Artificial Receptors Based on Assembly of Metal Complex Units and Desymmetrization of Molecular Components”
    Chem. Lett., 50, 1822–1830 (2021). (Award Highlight Review) (Link)